Evolving from single-celled yellow organisms at the dawn of time, Minions live to serve, but find themselves working for a continual series of unsuccessful masters, from T. Rex to Napoleon. Without a master to grovel for, the Minions fall into a deep depression. But one minion, Kevin, has a plan; accompanied by his pals Stuart and Bob, Kevin sets forth to find a new evil boss for his brethren to follow. Their search leads them to Scarlet Overkill, the world's first-ever super-villainess.
When aliens intercept video feeds of classic arcade games and misinterpret them as a declaration of war, they attack Earth, using the games as models. Knowing that he must employ a similar strategy, President Will Cooper (Kevin James) recruits his childhood pal, former video-game champ and home-theater installer Sam Brenner (Adam Sandler), to lead a team of old-school arcade players (Peter Dinklage, Josh Gad) and a military specialist (Michelle Monaghan) to save the planet.
When four people teleport to an alternate universe, which alters their physical form and grants them new abilities, they must learn to harness their abilities and work together as a team to save the Earth from a familiar enemy.